Goodbye Malaria has made a imprint in Mozambique, Swaziland and South Africa through their insecticide spraying campaign.
CEO Sherwn Charles said to date they have protected 250 000 people annually, which adds up to 50% less people in hospitals due to the disease.
"Before it was a child died every 30 seconds. Today, a child dies every 120 seconds. But it still starts will a child dies and that should not be the case," Charles said on Wednesday.
The organisation was launching two pop-up stores by young entrepreneur Lebohang Mokoena at the OR Tambo International Airport.
The stores sell locally produced merchandise that will raise funds for Goodbye Malaria.
They have groups on the ground that spray insecticide in homes in the most affected areas.
"Our aim at Goodbye Malaria is to eliminate malaria in southern Africa," Charles added.
He said: "In southern Africa we have at least three countries that are most likely to get there - Swaziland, South Africa and Mozambique."
Swaziland had 200 cases last year, SA had less than 10 000 cases and about 50% of those were most likely imported cases.
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